AENDO October 40/4

Barle, Hans, Björn Nyberg, Stig Ramel, Pia Essén, Margaret A. McNurlan, Jan Wernerman, and Peter J. Garlick. Inhibition of liver protein synthesis during laparoscopic surgery. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E591–E596, 1999.—Previous studies have indicated that laparoscopic surgery is associated with a decline in liver protein synthesis. In this study, the fractional synthesis rate (FSR) of total liver protein and albumin was measured in patients undergoing elective laparoscopic cholecystectomy at different times after commencing the procedure (n 5 8 1 8). Liver biopsy specimens were taken after 15 min of surgery in an ‘‘early’’ group and after 49 min of surgery in a ‘‘late’’ group. The liver FSR was higher in the early group (24.1 6 4.7%/day) compared with the late group (19.0 6 2.8%/day, P , 0.02). The fractional and absolute synthesis rates of albumin were similar in the two groups, 6.4 6 1.5 vs. 6.5 6 1.0%/day and 97 6 19 vs. 96 6 18 mg·kg21 ·day21 for the early and late groups, respectively. It is concluded that laparoscopic surgery was accompanied by a decrease in total liver protein synthesis rate, which developed rapidly during surgery. In contrast, no change in the synthesis rate of albumin was apparent during the course of surgery.